Experimental Vaccine for Deadly Tickborne Virus Effective in Cynomolgus Macaques
Published:02 Dec.2020    Source:NIH/National Institute of Allergy and Infectious Diseases

An experimental vaccine developed in Europe to prevent infection by Crimean-Congo hemorrhagic fever virus (CCHFV) has protected cynomolgus macaques in a new collaborative study from National Institutes of Health scientists. The animals received the DNA-based candidate vaccine through intramuscular injection immediately followed by electroporation -- a process in development for human vaccines that helps cells absorb DNA. The study, published in Nature Microbiology, comes about three years after the same research group developed the macaque model for CCHFV. No specific treatments or vaccines for CCHFV exist.

 
Collaborators at the Karolinska Institute in Sweden developed the candidate vaccine with colleagues from the Public Health Agency of Sweden, the National Veterinary Institute of Sweden, the Justus Liebig University in Germany and NIAID's Rocky Mountain Laboratories in Montana. The candidate vaccine uses two proteins from CCHFV to generate protection.