Yulin Zhou , Xiaofang Lin

Tropical Animal Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572025, China
Author    Correspondence author
Animal Molecular Breeding, 2024, Vol. 14, No. 1   doi: 10.5376/amb.2024.14.0002
Received: 03 Nov., 2023    Accepted: 17 Dec., 2023    Published: 08 Jan., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhou Y.L., and Lin X.F., 2024, Genetic resolution of disease resistance in poultry: a genome-wide association study perspective, Animal Molecular Breeding, 14(1): 10-18 (doi: 10.5376/amb.2024.14.0002)

Poultry diseases pose a serious threat to agricultural production, and resistance is one of the key factors for effective disease response. The aim of this study was to resolve the genetic basis of resistance in poultry through a genome-wide association study (GWAS) approach. A series of poultry populations stomach-selected for reference experimental subjects, including chickens, ducks and geese, were scanned genome-wide. Association analysis of thousands of loci successfully identified multiple genetic variants associated with poultry disease resistance. These variants are involved in key biological processes such as immune-related genes, inflammatory pathways and antiviral responses. Significant differences in resistance genotypes and frequencies were also found among different poultry breeds, which provide important clues for further improvement of poultry disease resistance.

Poultry diseases; Resistance; Genetic analysis; Genome-wide association studies; Immune genes