Xiaofang Lin

Tropical Animal Medicine Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China
Author    Correspondence author
Animal Molecular Breeding, 2024, Vol. 14, No. 2   
Received: 17 Feb., 2024    Accepted: 31 Mar., 2024    Published: 16 Apr., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study explores the application of CRISPR-Cas9 gene editing technology to enhance disease resistance in cattle. The CRISPR-Cas9 system has demonstrated significant potential in editing genes to confer disease resistance in livestock. Notable successes include the insertion of the NRAMP1 gene, which has been shown to increase resistance to bovine tuberculosis. The homology-mediated end-joining (HMEJ) method has further improved the efficiency of gene editing in cattle, leading to higher rates of successful gene integration and expression. This study highlights the feasibility and effectiveness of CRISPR-Cas9 in producing disease-resistant livestock. CRISPR-Cas9 gene editing represents a promising tool for enhancing disease resistance in cattle. The technology's ability to precisely modify specific genes associated with disease susceptibility offers a powerful approach to improving livestock health and reducing the economic impact of diseases. By targeting specific genes associated with disease resistance, this study to develop cattle that are more resilient to common and detrimental diseases, thereby improving livestock health and productivity.

CRISPR-Cas9; Gene editing; Disease resistance; Cattle; Livestock health