Review and Progress

Feline Calicivirus (FCV): From Molecular Characteristics to Vaccine Development Prospects  

Zhaolin Wang
Ruipai Pet Hospital, Sanya, 572022, Hainan, PR China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2023, Vol. 13, No. 2   doi: 10.5376/ijmvr.2023.13.0002
Received: 13 Nov., 2023    Accepted: 03 Jan., 2024    Published: 18 Dec., 2023
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Wang Z.L., 2023, Feline calicivirus (FCV): from molecular characteristics to vaccine development prospects, International Journal of Molecular Veterinary Research, 13(2): 1-10 (doi: 10.5376/ijmvr.2023.13.0002)


Feline calicivirus (FCV) is a significant pathogen affecting the health of feline animals, characterized by a high degree of genetic variability, which complicates vaccine prevention and control strategies. This study provides a comprehensive review of FCV's molecular characteristics, epidemiology, infection mechanisms, host immune responses, and the current state of vaccine development. It systematically analyzes the structure and genomic composition of FCV, reveals key molecular mechanisms in the virus replication cycle, and discusses the impact of virus variability and genetic polymorphism on vaccine design. Additionally, this study reviews the modes of FCV transmission, clinical symptoms, diagnostic methods, and the host's immune response to FCV. Furthermore, in light of the limitations of existing vaccines, this research explores the prospects of emerging vaccine technologies, such as genetically engineered vaccines, virus-like particle (VLP) vaccines, DNA vaccines, and mRNA vaccines. It further identifies the challenges and research directions in the future development of FCV vaccines, underscores the importance of an integrated epidemic control strategy, and proposes key points for future research.

Feline calicivirus (FCV); Molecular characteristics; Immune response; Vaccine development; Virus variation
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