Siping Zhang , Haiyong Chen

Tropical Veterinary Medicine Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572024, China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 1   doi: 10.5376/ijmvr.2024.14.0004
Received: 01 Dec., 2023    Accepted: 12 Jan., 2024    Published: 02 Feb., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Zhang S.P., and Chen H.Y., 2024, Research on the threat of H5N1 avian influenza virus to chicken health and its molecular mechanisms, International Journal of Molecular Veterinary Research, 14(1): 23-31 (doi: 10.5376/ijmvr.2024.14.0004)

With the repeated outbreaks of the H5N1 avian influenza virus, in-depth research on its threat to chicken health and its molecular mechanism has become particularly urgent. This study aims to comprehensively analyze the characteristics and transmission routes of H5N1 avian influenza virus, as well as the impact on clinical symptoms and production performance of chickens after infection. Through in-depth research on the interaction between viruses and hosts, the key mechanisms of virus invasion into host cells and the regulatory process of host immune responses have been revealed, providing strong support for understanding the molecular mechanisms of infection. Research results show that infection with the H5N1 avian influenza virus not only causes respiratory symptoms, but also has a significant impact on the production performance of chickens, including reduced egg production and slowed growth. At the molecular level, viruses rely on sophisticated gene expression and regulatory mechanisms to closely interact with host cells to form a complex network of infection. Future research directions include in-depth exploration of the mutation and evolution mechanisms of the H5N1 avian influenza virus, strengthening research on the interaction between the virus and the host immune system, and establishing a more sensitive early warning system. This study provides a scientific basis for formulating more effective prevention and control strategies, and provides an important reference for protecting the poultry industry and human health.

H5N1 avian influenza virus; Chicken health; Molecular mechanisms; Virus variation; Early warning