Zhenni Lu

Hangzhou Luohuashi Biotechnology Co., Ltd, Hangzhou, 310000, China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 1   doi: 10.5376/ijmvr.2024.14.0005
Received: 08 Dec., 2023    Accepted: 17 Jan., 2024    Published: 09 Feb., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Lu Z.N., 2024, Study on the effect of temperature on epigenetic marks in mice, International Journal of Molecular Veterinary Research, 14(1): 32-39 (doi: 10.5376/ijmvr.2024.14.0005)

This study reviews studies on the effects of temperature on epigenetic marks in mice. As an important experimental model, mice achieve adaptive changes in physiological functions by regulating epigenetic marks when adapting to changes in environmental temperature. This study first introduces the physiological characteristics and temperature adaptation mechanism of mice, and then provides a systematic overview of the basic knowledge of epigenetics, including DNA methylation, histone modifications, and non-coding RNA. This study also explored in detail the effect of temperature on epigenetic marks in mice, including its regulatory effects on DNA methylation, histone modifications and non-coding RNAs. The association mechanism between epigenetic marks and temperature adaptation in mice was further analyzed, and its clinical significance and application prospects in related diseases were explored. This study provides an outlook on future research directions and application prospects, and emphasizes the importance of in-depth study of the relationship between temperature adaptive regulation and epigenetic marks in mice to understand the adaptation mechanism of organisms to environmental changes and the pathogenesis of diseases.

Mice; Temperature adaptation; Epigenetic marks; DNA methylation; Histone modification; Non-coding RNA