Jim Mason

International Journal of Molecular Veterinary Research, AnimalSci Publisher, Richmond, BC, V7A4Z5, Canada
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 2   doi: 10.5376/ijmvr.2024.14.0006
Received: 01 Jan., 2023    Accepted: 10 Feb., 2024    Published: 01 Mar., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Mason J., 2024, Instantaneous manipulation: dynamic regulation of eomes in early mouse embryonic development, International Journal of Molecular Veterinary Research, 14(2): 40-45 (doi: 10.5376/ijmvr.2024.14.0006)

The paper "A degron-based approach to manipulate Eomes functions in the context of the developing mouse embryo" published in the journal Proceedings of National Academy of Sciences of the United States of America on October 31, 2023, was written by Alexandra M. Bisia, Ita Costello, Maria-Eleni Xypolita, Luke TG Harland, etc., from the Sir William Dunn School of Pathology, University of Oxford, Oxford, UK. The study explored the function and role of this gene in different developmental stages of mouse embryos by constructing Eomes gene variants containing a degradation fusion tag (dTAG). By using the dTAG system, researchers can quickly and specifically induce the degradation of Eomes protein through small molecule intervention in both in vitro and in vivo environments, thereby revealing the key role of Eomes in embryonic development, and also demonstrating the application potential and flexibility of dTAG technology in studying gene function.

Dynamic regulation; Eomes; Mouse