Xiaofang Lin

Tropical Animal Medicine Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 4   
Received: 24 May, 2024    Accepted: 28 Jun., 2024    Published: 16 Jul., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study investigated the functional roles of key ASFV genes related to pathogenesis and immune evasion, providing insights into the molecular mechanisms of virus replication, host cell entry, and immune suppression. The main structures and regulatory genes were studied, including p72 (B646L) responsible for capsid formation and host cell entry, as well as the regulatory factor A104R for viral DNA replication. The role of A238L, EP402R (CD2v), and DP71L genes in immune evasion was also analyzed, emphasizing the ASFV induced apoptosis, necrosis, and necrosis pathways leading to tissue damage. A case study of ASFV outbreak in Eastern Europe provides genomic insights into the prevalent strain and evaluates current control measures. The aim of this study is to emphasize potential vaccine targets and strategies for structural protein and gene deletion to reduce the virulence of the virus, promote genomic analysis of African swine fever virus, develop novel antiviral drugs, and collaborate efforts to achieve long-term eradication.

African swine fever virus; Pathogenesis; Immune evasion; ASFV genes; Vaccine development