Xiaofang Lin

Tropical Animal Medicine Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 5   doi: 10.5376/ijmvr.2024.14.0021
Received: 03 Sep., 2024    Accepted: 05 Oct., 2024    Published: 16 Oct., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Lin X.F., 2024, Dissecting the role of virulence genes in ASFV: a molecular perspective, International Journal of Molecular Veterinary Research, 14(5): 185-193 (doi: 10.5376/ijmvr.2024.14.0021)

This study aims to dissect the molecular mechanisms behind ASFV virulence by focusing on its genome, key virulence factors, and interactions with host immune systems. Through an extensive review of current literature, we examine the structure and replication mechanisms of ASFV, along with the identification of critical virulence genes and their roles in immune modulation, apoptosis inhibition, and pathogenesis. Special attention is given to the A179L gene, a prominent virulence factor in ASFV, through a case study that highlights its impact on immune evasion. Additionally, the study explores the genetic variation of ASFV strains, their virulence properties, and the host's resistance mechanisms. Diagnostic tools, potential biomarkers for virulence assessment, and future directions for vaccine and antiviral development are also discussed. The findings provide essential insights into the genetic and molecular factors that contribute to ASFV virulence, with an emphasis on developing more effective diagnostic and therapeutic strategies to control ASF outbreaks. This study anticipates further advancements in ASFV research, ultimately leading to improved public health interventions and economic stability in the swine industry.

African swine fever virus; Virulence genes; Immune evasion; A179L gene; ASFV pathogenesis