guo tianxia

Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No.   
Received: 01 Jan., 1970    Accepted: 01 Jan., 1970    Published: 17 Mar., 2025

This study aims to dissect the molecular mechanisms behind ASFV virulence by focusing on its genome, key virulence factors, and interactions with host immune systems. Through an extensive review of current literature, we examine the structure and replication mechanisms of ASFV, along with the identification of critical virulence genes and their roles in immune modulation, apoptosis inhibition, and pathogenesis. Special attention is given to the A179L gene, a prominent virulence factor in ASFV, through a case study that highlights its impact on immune evasion. Additionally, the study explores the genetic variation of ASFV strains, their virulence properties, and the host's resistance mechanisms. Diagnostic tools, potential biomarkers for virulence assessment, and future directions for vaccine and antiviral development are also discussed. The findings provide essential insights into the genetic and molecular factors that contribute to ASFV virulence, with an emphasis on developing more effective diagnostic and therapeutic strategies to control ASF outbreaks. This study anticipates further advancements in ASFV research, ultimately leading to improved public health interventions and economic stability in the swine industry.