Xiaofang Lin

Tropical Animal Medicine Research Center, Hainan Institute of Tropical Agricultural Resources, Sanya, 572000, Hainan, China
Author    Correspondence author
International Journal of Molecular Veterinary Research, 2024, Vol. 14, No. 6   doi: 10.5376/ijmvr.2024.14.0028
Received: 03 Nov., 2024    Accepted: 08 Dec., 2024    Published: 20 Dec., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Lin X.F., 2024, Disease resistance in canids: genetic variations between wild wolves and domestic dogs, International Journal of Molecular Veterinary Research, 14(6): 244-253 (doi: 10.5376/ijmvr.2024.14.0028)

This study explores the comparative genomics of wild wolves and domestic dogs, focusing on genetic differences influencing immunity and disease susceptibility. Using genome-wide association studies (GWAS) and whole-genome sequencing, we identified key genes involved in immune responses and analyzed the effects of domestication on immune gene diversity. Furthermore, evolutionary and ecological factors, including habitat and behavior, were examined for their roles in shaping disease resistance. A case study on rabies resistance in wild wolves highlights adaptive genetic mechanisms and their conservation implications. The findings advance our understanding of canid immunogenomics and suggest strategies for breeding disease-resistant dogs, conserving genetic diversity in wolves, and improving zoonotic disease management. This research bridges genomics with practical applications in veterinary science and wildlife conservation, offering pathways for future exploration of genetic resilience in canids.

Canid genomics; Disease resistance; Wild wolves; Domestic dogs; Immune gene diversity